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Homocysteine — Cardiovascular Risk Factor: Range, Interpretation

Updated: June 2025

Homocysteine is a sulfur-containing amino acid, an intermediate in methionine metabolism. Elevated levels are an independent risk factor for atherosclerosis, thrombosis, and pregnancy complications.

Reference Range

5–15 мкмоль/л

Causes of Elevation

  • Deficiency of vitamins B6, B12, folic acid
  • Genetic mutations (MTHFR)
  • Renal failure
  • Hypothyroidism
  • Smoking
  • Certain medications (methotrexate, carbamazepine)

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