Basophils
Disclaimer: Information on this page is for educational purposes. Consult a physician to interpret your test results. Health Vault helps track biomarker trends but does not replace medical advice.
What This Test Measures
Basophils are rare granulocytes involved in allergic and inflammatory reactions through histamine and heparin release. They typically comprise less than 1% of blood leukocytes.
Basophilia may occur in myeloproliferative neoplasms (especially CML), chronic urticaria, and recovery after acute allergic reactions. Significant elevation is uncommon but may indicate serious hematologic disease.
Basopenia is usually not clinically significant and is often associated with acute stress or hyperthyroidism.
Normal Ranges
| Group | Reference Range |
|---|---|
| Men | 0–1% (<0.1 × 10⁹/L) |
| Women | 0–1% (<0.1 × 10⁹/L) |
| Children | 0–1% |
Reference ranges may vary by laboratory and assay method.
Causes of High Levels
- CML and myeloproliferative neoplasms
- Chronic urticaria
- Recovery after allergic reaction
- Hypothyroidism (rare)
Causes of Low Levels
- Acute stress, hyperthyroidism
- Corticosteroids
- Usually not clinically significant
Test Preparation
- No preparation required
Related Biomarkers
| Biomarker | Relationship |
|---|---|
| Eosinophils | Co-signaling in allergy |
| White Blood Cells | Total leukocyte count |
| Neutrophils | Granulocyte fraction |
FAQ
How often should I take this test?
With CBC — annually; if CML suspected — specialized workup.
What should I do if my result is abnormal?
Persistent basophilia >2% — hematology consult to rule out myeloproliferative disease.
Last updated: June 2026